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Quick Lincs
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John L. Rinn is an assistant professor
of Stem Cell and Regerative Biology
at Harvard University and Medical
School and Senior Associate Member
of the Broad Institute. Our research
aims to understand the role of long non-coding RNAs (lncRNAs)
in establishing the distinct epigenetic
states of adult and embryonic cells
and their misregulation in diseases
such as cancer. To further explore
how lncRNAs may define and or drive
cell fate decisions we developed
computational methods to provide
initial hypothesis of their functions.
This “guilt by association method”
pointed to a clear connection of
lncRNAs and numerous cellular pathways
ranging from pluripotency, cancer,
adipogenesis to parasitology. We
have employed systematic compuational
and experimental approaches that
have unraveled a myriad of functional
roles for lncRNAs in these pathways.
Collectively our studies point to
key regulatory roles for lncRNAs
across diverse biological pathways,
with a common theme of forming ribonucleic-protein
complexes that in turn modulate
cell fate decisions. Overall, we aim to understand lncRNAs physiological and disease roles in vivo from Mouse Models to Molecular Mechanisms.
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